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Viewing All Flashcards for Antianxiety and Hypnotics
Questions
Answers
1)
Mechanism of action of BZDSWhere do BZDs bind on the GABA receptor?
 
GABA-A Receptor/Cl ionophore complex.
2)
Mechanism of action of BZDsHow do BZDs produce their effect?
 
Act allosterically to increase the frequency of Cl- channel opening. Enhances hyperpolarizing effect of GABA
3)
Pharmacological Effects of BZDs       
 
Behavioral Changes, Skeletal Muscle Relaxation, Inhibition of Seizure Activity, Drowsiness and Sleep
4)
What do BZDs do to inhibit seizure activity?   
 
Prevent seizure spread, not electrical events at seizure focus.
5)
What activity is affected under the sedative hypnotic effects of BZDs? and How?       
 
Decreased alpha activity.
6)
How are sleep stages altered by BZDs?   
 
Decreased sleep latency, increased sleep time, shortens stage 4 (deep) sleep, shortens REM sleep
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