Private Flashcard From Lippincott's - Ch. 21
What happens in response to these drugs?
The synthesis of cytochrome P450 proteins increases, leading to an enhanced consumption of heme - a component of cytochrome P450 proteins. This, in turn, causes a decrease in the concentration of heme in liver cells. The lower intracellular heme concentration leads to an increase in the synthesis of ALAS1 (derepression), and prompts a corresponding increase in ALA synthesis.