Lippincott's - Ch. 21
 |
Lippincott's - Ch. 21
Total Views: 9112
Teams This Deck Belongs To
Flashcard Deck Tags
Flashcard Review
Deck Author
 |
Others Studying this Deck
Private Flashcard From Lippincott's - Ch. 21
Question:
What happens in response to these drugs?
Answer:
The synthesis of cytochrome P450 proteins increases, leading to an enhanced consumption of heme - a component of cytochrome P450 proteins. This, in turn, causes a decrease in the concentration of heme in liver cells. The lower intracellular heme concentration leads to an increase in the synthesis of ALAS1 (derepression), and prompts a corresponding increase in ALA synthesis.