Chapter 14

Last update by Shanal on 10/20/2013
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Karen and Steve each have a sibling with sickle-cell disease. Neither Karen nor Steve nor any of their parents have the disease, and none of them have been tested to reveal sickle-cell trait. Based on this incomplete information, calculate the probability that if this couple has a child, the child will have sickle-cell disease.

Answer:
1/9

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    Answered in Chapter 14

    In 1981, a stray black cat with unusual rounded, curled-back ears was adopted by a family in California. Hundreds of descendants of the cat have since been born, and cat fanciers hope to develop the curl cat into a show breed. Suppose you owned the first curl cat and wanted to develop a true-breeding variety. How would you determine whether the curl allele is dominant or recessive? How would you obtain true-breeding curl cats? How could you be sure they are true-breeding?

    Matings of the original mutant cat with true-breeding noncurl cats will produce both curl and noncurl F1 offspring if the curl allele is dominant, but only noncurl offspring if the curl allele is recessive. You would obtain some true-breeding offspring homozygous for the curl allele from matings between the F1 cats resulting from the original curl × noncurl crosses whether the curl trait is dominant or recessive. You know that cats are true-breeding when curl × curl matings produce only curl offspring. As it turns out, the allele that causes curled ears is dominant