Chapter 11

Last update by mayur on 04/07/2014
846386 People have viewed this Quiz
  • Share

Which of the following would be inhibited by a drug that specifically blocks the addition ofphosphate groups to proteins?

A) G-protein-linked receptor signaling

B) ligand-gated ion channel signaling

C) adenylyl cyclase activity

D) phosphatase activity

E) receptor tyrosine kinase activity



Answer:

E) receptor tyrosine kinase activity



View Chapter 11 as Flashcard Deck

Related Quiz Content
  • feldman2009
    Answered in Chapter 11

    Which of the following most likely would be an immediate result of growth factor binding to its receptor?

    A) protein kinase activity

    B) adenylyl cyclase activity

    C) GTPase activity

    D) protein phosphatase activity

    E) phosphorylase activity


    A) protein kinase activity


  • feldman2009
    Answered in Chapter 11

    An inhibitor of phosphodiesterase activity would have which of the following effects?

    A) block the response of epinephrine

    B) decrease the amount of cAMP in the cytoplasm

    C) block the activation of G proteins in response to epinephrine binding to its receptor

    D) prolong the effect of epinephrine by maintaining elevated cAMP levels in the cytoplasm

    E) block the activation of protein kinase A



    D) prolong the effect of epinephrine by maintaining elevated cAMP levels in the cytoplasm



  • feldman2009
    Answered in Chapter 11

    Adenylyl cyclase has the opposite effect of which of the following?

    A) protein kinase

    B) protein phosphatase

    C) phosphodiesterase

    D) phosphorylase

    E) GTPase



    C) phosphodiesterase



  • feldman2009
    Answered in Chapter 11

    Caffeine is an inhibitor of phosphodiesterase. Therefore, the cells of a person who hasrecently consumed coffee would have increased levels of

    A) phosphorylated proteins.

    B) GTP.

    C) cAMP.

    D) adenylyl cyclase.

    E) activated G proteins.



    C) cAMP.



  • feldman2009
    Answered in Chapter 11

    If a pharmaceutical company wished to design a drug to maintain low blood sugar levels, oneapproach might be to

    A) design a compound that blocks epinephrine receptor activation.

    B) design a compound that inhibits cAMP production in liver cells.

    C) design a compound to block G-protein activity in liver cells.

    D) design a compound that inhibits phosphorylase activity.

    E) All of the above are possible approaches.



    E) All of the above are possible approaches.



  • feldman2009
    Answered in Chapter 11

    An inhibitor of which of the following could be used to block the release of calcium from the

    endoplasmic reticulum?

    A) tyrosine kinases

    B) serine/threonine kinases

    C) phosphodiesterase

    D) phospholipase C

    E) adenylyl cyclase





    D) phospholipase c
  • feldman2009
    Answered in Chapter 11

    Which of the following statements is true?

    A) When signal molecules first bind to receptor tyrosine kinases, the receptors phosphorylate anumber of nearby molecules.

    B) In response to some G-protein-mediated signals, a special type of lipid molecule associatedwith the plasma membrane is cleaved to form IP3 and calcium.

    C) In most cases, signal molecules interact with the cell at the plasma membrane and then enterthe cell and eventually the nucleus.

    D) Toxins such as those that cause botulism and cholera interfere with the ability of activated Gproteins to hydrolyze GTP to GDP, resulting in phosphodiesterase activity in the absence of anappropriate signal molecule.

    E) Protein kinase A activation is one possible result of signal molecules binding to G protein-linked receptors.



    E) Protein kinase A activation is one possible result of signal molecules binding to G protein-linked receptors.



  • feldman2009
    Answered in Chapter 11

    Which of the following is a correct association?

    A) kinase activity and the addition of a tyrosine

    B) phosphodiesterase activity and the removal of phosphate groups

    C) GTPase activity and hydrolysis of GTP to GDP

    D) phosphorylase activity and the catabolism of glucose

    E) adenylyl cyclase activity and the conversion of cAMP to AMP



    C) GTPase activity and hydrolysis of GTP to GDP



  • feldman2009
    Answered in Chapter 11

    One inhibitor of cGMP is Viagra. It provides a signal that leads to dilation of blood vesselsand increase of blood in the penis, facilitating erection. cGMP is inhibited, therefore the signal isprolonged. The original signal that is now inhibited would have

    A) hydrolyzed cGMP to GMP.

    B) hydrolyzed GTP to GDP.

    C) phosphorylated GDP.

    D) dephosphorylated cGMP.

    E) removed GMP from the cell.



    A) hydrolyzed cGMP to GMP.



  • feldman2009
    Answered in Chapter 11

    A drug designed to inhibit the response of cells to testosterone would almost certainly resultin which of the following?

    A) lower cytoplasmic levels of cAMP

    B) an increase in receptor tyrosine kinase activity

    C) a decrease in transcriptional activity of certain genes

    D) an increase in cytosolic calcium concentration

    E) a decrease in G-protein activity

    C) a decrease in transcriptional activity of certain genes



  • feldman2009
    Answered in Chapter 11

    Which of the substances below is a protein that can hold several other relay proteins as itbinds to an activated membrane receptor?

    A) active transcription factor

    B) third messenger

    C) ligand

    D) scaffolding protein

    E) protein kinase



    D) scaffolding protein